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Bacopa monnieri, also known as water hyssop, is an herb commonly used in Ayurveda. Studies have shown that supplementing Bacopa can support overall cognitive function, both by supporting memory formation and by helping to manage occasional stress. Bacopa supports both the dopaminergic and serotonergic systems but works mainly by supporting the rate at which neurons communicate by increasing the proliferation of dendrites (nerve endings), thus facilitating communication between brain cells. Our Bacopa extract is standardized to 20% bacosides (the active ingredient in the Bacopa herb).
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Bacopa can increase a chemical in the body called acetylcholine. Acetylcholine plays a big part in many important body functions. Some medications, called anticholinergic drugs, block the effects of acetylcholine in the body. Taking bacopa might decrease the effects of anticholinergic drugs.
Bacopa can increase a chemical in the body called acetylcholine. Some medications that are used for glaucoma, Alzheimer disease, and other conditions, also increase acetylcholine levels. Taking bacopa with these medications might increase the chance of side effects.
The body naturally produces thyroid hormones. Bacopa might increase how much thyroid hormone is produced. Taking bacopa with thyroid hormone might cause too much thyroid hormone in the body, and increase its effects and side effects.
Ethnopharmacological relevance: Bacopa monnieri (L.) Wettst., a plant belonging to the family Scrophulariaceae, has been used in the traditional system of Ayurvedic medicine to improve intelligence and memory for a long time. Therefore, the potential of this plant to protect against Alzheimer's disease has been raised but less supported document is available.
Aim of the study: To determine the effect of alcoholic extract of Bacopa monnieri on cognitive function and neurodegeneration in animal model of Alzheimer's disease induced by ethylcholine aziridinium ion (AF64A).
Materials and methods: Male Wistar rats were orally given the alcoholic extract of Bacopa monnieri at doses of 20, 40 and 80 mg/kg BW via feeding needle for a period of 2 weeks before and 1 week after the intracerebroventricular administration of AF64A bilaterally. Rats were tested for spatial memory using Morris water maze test and the density of neurons and cholinergic neurons was determined using histological techniques 7 days after AF64A administration.
Neurodegenerative Parkinson's disease (PD) is associated with aggregation of protein alpha synuclein and selective death of dopaminergic neurons, thereby leading to cognitive and motor impairment in patients. The disease has no complete cure yet; the current therapeutic strategies involve prescription of dopamine agonist drugs which turn ineffective after prolonged use. The present study utilized the powerful genetics of model system Caenorhabditis elegans towards exploring the anti-Parkinsonian effects of a neuro-protective botanical Bacopa monnieri. Two different strains of C. elegans; a transgenic model expressing "human" alpha synuclein [NL5901 (P(unc-54)::alphasynuclein::YFP+unc-119)], and a pharmacological model expressing green fluorescent protein (GFP) specifically in the dopaminergic neurons [BZ555 (P(dat-1)::GFP)] treated with selective catecholaminergic neurotoxin 6-hydroxy dopamine (6-OHDA), were employed for the study. B. monnieri was chosen for its known neuroprotective and cognition enhancing effects. The study examined the effect of the botanical, on aggregation of alpha synuclein, degeneration of dopaminergic neurons, content of lipids and longevity of the nematodes. Our studies show that B. monnieri reduces alpha synuclein aggregation, prevents dopaminergic neurodegeneration and restores the lipid content in nematodes, thereby proving its potential as a possible anti-Parkinsonian agent. These findings encourage further investigations on the botanical, and its active constituent compounds, as possible therapeutic intervention against Parkinson's disease.
This review synthesizes behavioral research with neuromolecular mechanisms putatively involved with the low-toxicity cognitive enhancing action of Bacopa monnieri (BM), a medicinal Ayurvedic herb. BM is traditionally used for various ailments, but is best known as a neural tonic and memory enhancer. Numerous animal and in vitro studies have been conducted, with many evidencing potential medicinal properties. Several randomized, double-blind, placebo-controlled trials have substantiated BM's nootropic utility in humans. There is also evidence for potential attenuation of dementia, Parkinson's disease, and epilepsy. Current evidence suggests BM acts via the following mechanisms-anti-oxidant neuroprotection (via redox and enzyme induction), acetylcholinesterase inhibition and/or choline acetyltransferase activation, β-amyloid reduction, increased cerebral blood flow, and neurotransmitter modulation (acetylcholine [ACh], 5-hydroxytryptamine [5-HT], dopamine [DA]). BM appears to exhibit low toxicity in model organisms and humans; however, long-term studies of toxicity in humans have yet to be conducted. This review will integrate molecular neuroscience with behavioral research.
This herb plant is prized for its medicinal properties. Used for centuries in traditional Ayurvedic medicine, Brahmi, issued to cure epilepsy and as an anti-aging cure all. It has been proven in contemporary medical studies as an effective treatment for improving memory, anxiety, stomach ailments and as a general tonic to fight stress. It's flavonoid and alkaloid chemical content make it a valuable medicinal herb.Brahmi plants practically grow themselves. Thriving under substandard conditions, the brahmi herb prefers consistently moist to wet soil and can even grow in water gardens. Try planting in a marshy area such as by a pond or river embankment. This creeping herb makes a great ground cover and blooms continuously from Spring to late Fall. Make sure to prune back every other year as Brahmi plants can be somewhat invasive if not kept in check. We are proud to offer bacopa monnieri plants for sale.If you plan to use the Bacopa Monnieri plant medically, be aware that there may be some side effects. Bacopa may also interact adversely with other medication, so make sure to consult your doctor before using.
Alzheimer disease (AD) is characterized by dementia that begins as mild short term memory deficit and culminates in total loss of cognitive and executive functions. The present study was conducted to evaluate the neuroprotective potential of Bacopa monnieri (BM), an Indian traditional medicinal plant effective against cognitive impairment, in colchicine-induced dementia. Intracerebroventricular administration of colchicine (15 μg/5 μl) induced cognitive impairment in rats as assessed by elevated plus maze. This was accompanied by a significant increase in oxidative stress in term of enhanced levels of lipid peroxidation and protein carbonyls. Concomitantly, decrease in activity of antioxidant enzymes was observed in colchicine treated animals. BM (50 mg/kg body weight) supplementation reversed memory impairment observed in the colchicine treated rats. BM administration attenuated oxidative damage, as evident by decreased LPO and protein carbonyl levels and restoration in activities of the antioxidant enzymes. The activity of membrane bound enzymes (Na(+)K(+) ATPase and AChE) was altered in colchicine treated brain regions and BM supplementation was able to restore the activity of enzymes to comparable values observed in controls. The results suggest therapeutic potential of BM in the treatment of AD associated cognitive decline.
Bacopa monnieri is an herb that grows in marshy wetlands and tropical regions. It goes by many names, including brahmi, water hyssop, and herb of grace. Ayurvedic traditional remedies use bacopa to improve cognition, relieve stress, reduce inflammation, and enhance longevity. Modern research shows that Bacopa monnieri may be beneficial for boosting cognition, alleviating stress, reducing inflammation, and more.
Bacopa monnieri is rich in an antioxidant compound called bacosides. It may boost levels of other antioxidants as well, including superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH). Researchers have hypothesized that the bacosides are responsible for much of the claims that bacopa can reduce stress, enhance longevity, and boost cognitive function. Bacosides protect against oxidative stress by scavenging free radicals and preventing lipid peroxidation. Lipid peroxidation occurs when oxidants steal electrons from the lipids in cell membranes, ultimately causing damage to the cell. Free radicals also cause oxidative stress, inflammation, and premature cellular aging.
Bacopa helps modulate the stress response and may minimize the intensity of perceived stressors. A human study found that bacopa exerts anxiolytic effects by reducing levels of the stress hormone cortisol. Researchers also confirmed bacopa has adaptogenic properties and improves mood during periods of stress.
Nootropic supplements primarily exert effects on several areas of cognition, including memory, alertness, and overall function. Bacopa monnieri appears to exert nootropic effects on individuals of all ages. Human studies hold strong promise. Bacopa supplements successfully improved information retention, retention speed, rate of learning, verbal learning, and overall memory in healthy adults ranging from the ages of 18 to 60. Another study reported similar effects in elderly adults.
Taking Bacopa monnieri powder on an empty stomach may cause gastrointestinal side effects. These include nausea, bloating, stomach cramps, and diarrhea. Take bacopa supplements with food to mitigate these side effects. Individuals taking amitriptyline should consult with a physician before taking Bacopa monnieri supplements, as bacopa may enhance the bioavailability of this medication. 041b061a72